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Liu Shuai

About

  • Department: School of Psychology and Cognitive Science
  • Gender: male
  • Post: Research Professor
  • Graduate School:
  • Degree: PhD
  • Academic Credentials:
  • Tel: 86-021-62233365
  • Email: sliu@psy.ecnu.edu.cn
  • Office: 305 Old Library Building
  • Address: 3663 North Zhongshan Road, Shanghai
  • PostCode: 200062
  • Fax:

Education

WorkExperience

Resume

Dr. Shuai Liu is a principal investigator at the Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University (ECNU). Prior to joining ECNU, Dr. Liu received his PhD from Fudan University and was a postdoctoral scholar at the University of British Columbia and Hotchkiss Brain Institute at the University of Calgary.

Dr. Liu’s research primarily focuses on how feeding peptides and diet modulate neuroplasticity in the central reward system. His work has demonstrated that insulin in the Ventral Tegmental Area (VTA) suppresses excitatory synaptic transmission and reduces food cue related behaviours. This effect is disrupted during pathological hyperinsulinemia and may lead to increased feeding. Even a short-term exposure to palatable foods can drive future feeding behaviour by “rewiring” mesolimbic dopamine neurons.

Research Interests:

Dr. Liu’s research goal is to address one of the most fundamental questions in neuroscience: how does the brain work for hedonic feeding. Using a combination of electrophysiology, immunochemistry, behavioral task approaches, the research is conducted in the following three directions:

1. Feeding peptide effects on neuroplasticity in the reward system and hedonic feeding

2. Dissection of neural circuits for motivation and decision-making in hedonic feeding

3. Neural mechanisms underlying metabolic syndrome induced reward circuitry dysfunction 


Other Appointments

Research Fields

Dr. Liu’s research goal is to address one of the most fundamental questions in neuroscience: how does the brain work for hedonic feeding. Using a combination of electrophysiology, immunochemistry, behavioral task approaches, the research is conducted in the following three directions:

1. Feeding peptide effects on neuroplasticity in the reward system and hedonic feeding

2. Dissection of neural circuits for motivation and decision-making in hedonic feeding

3. Neural mechanisms underlying metabolic syndrome induced reward circuitry dysfunction

Enrollment and Training

Course

Scientific

Academic Achievements

Publications:

1.Liu S,Borgland SL. (2019) Insulin actions in the mesolimbic dopamine system. ExperimentalNeurology, 113006.doi:10.1016/j.expneurol.2019.113006

2.Mills F*, Globa AK*, Liu S, Cowan CM, Mobasser M, Phillips AG, Borgland SL &Bamji SX. (2017) Cadherins mediate cocaine-induced synaptic plasticity andbehavioral conditioning. Nature Neuroscience.DIO:10.1038/nn.4503

3.Ferrario CR*, Labouèbe G*, Liu S*, Nieh EH*, Routh VH*, XuS*, O’Connor EC. (2016) Homeostasis Meets Motivation in the Battle to ControlFood Intake. Journal of Neuroscience 36 (45) 11469-11481. (* 共同第一作者)

4.Liu S,Globa AK, Mills F, Naef L, Qiao M, Bamji SX, Borgland SL. (2016) Consumption ofpalatable food primes food approach behaviour by rapidly increasing synapticdensity in the VTA. Proc. Natl. Acad. Sci. U.S.A. 113(9): 2520-2525. DOI:10.1073/pnas.1515724113

5.ThompsonJL, Yang J, Lau B, Liu S,Baimel C, Kerr LE, Liu F, Borgland SL. (2015) Age-Dependent D1-D2 ReceptorCoactivation in the Lateral Orbitofrontal Cortex Potentiates NMDA Receptors andFacilitates Cognitive Flexibility.Cereb.Cortex. DOI: 10.1093/cercor/bhv222

6.Liu S, Borgland SL. (2015) Regulationof the mesolimbic dopamine circuit by feeding peptides. Neuroscience. 10:289C:19-42

7.Ferris MJ,Milenkovic M, Liu S, MielnikCA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL,Jones SR, Ramsey AJ. (2014) SustainedNMDA receptor hypofunction remodels the dopamine system and impairs phasicsignaling. Eur J Neurosci.40(1):2255-63.

8.Labouèbe G*,LiuS*, Dias C, Zou H,Wong JC, Karunakaran S, Clee SM, Phillips AG, Boutrel B, Borgland SL.(2013) Insulin induces long-term depression of ventral tegmental area dopamineneurons via endocannabinoids. Nature Neuroscience. 16(3):300-8. (* 共同第一作者)

9.Liu S*, Labouèbe G*, Karunakaran S, Clee SM, BorglandSL. (2013) Effect of insulin on excitatorysynaptic transmission onto dopamine neurons of the ventral tegmental area in amouse model of hyperinsulinemia. Nutrition & Diabetes. 16;3:e97. (* 共同第一作者)

10.LiuS,Zheng P. (2013) Altered PKA modulation in the Nav1.1 epilepsy variant I1656M. JNeurophysiol. 110(9):2090-8.

11.Liu GX, Liu S, Cai GQ, Sheng ZJ, Cai YQ,Jiang J, Sun X, Ma SK, Wang L, Wang ZG, Fei J. (2007) Reduced aggression in micelacking GABA transporter subtype 1 J Neurosci Res. 15: 85(3):649-55.


Book Chapter:

Liu S, Labouebe G and Borgland S. (2014) Insulin induces long-term depression in VTA DA neurons via an endocannabinoid -mediated mechanism In: Catecholamine Research in the 21st Century. Editor: Lee E. Eiden; p253


國家專利：

1. 國家實用(yòng)新型專利：一種獨立式節律監控裝置；申請号/專利号：201922129810.8（專利授權）

2. 國家發明(míng)專利：一種獨立式節律監控裝置；申請号/專利号：201911217674.6 （發明(míng)公布）


Honor